Claims
Rh incompatibility caused hemolytic disease of the newborn in later pregnancies before Rh immune globulin prophylaxis was introduced in 1968
Documented · occurred What these labels mean →When an RhD-negative mother is exposed to RhD-positive fetal red cells, she develops anti-D antibodies that cross the placenta and destroy fetal red cells, causing hemolytic disease of the fetus and newborn. Its incidence has decreased substantially since Rh immune globulin (anti-D prophylaxis) was introduced in 1968.
Evidence
| Relation | Record | Note |
|---|---|---|
| documents | eutils.ncbi.nlm.nih.gov | Blood Rev 2000;14(1):44-61 (abstract): RhD-negative mother exposed to RhD-positive cells 'develops allo-anti-D which crosses the placenta and then results in the destruction of fetal red cells'; anti-D immunoglobulin prophylaxis developed |
| documents | eutils.ncbi.nlm.nih.gov | Clin Perinatol 2004;31(4):721-42 (abstract): incidence 'has decreased substantially since Rh immune globulin was introduced in 1968' |
Sources
| Source | Relation | At |
|---|---|---|
| Basques and Atlantis (Why Files 2026) | reports |
Claim
When an RhD-negative mother is exposed to RhD-positive fetal red cells, she develops anti-D antibodies that cross the placenta and destroy fetal red cells, causing hemolytic disease of the fetus and newborn. Its incidence has decreased substantially since Rh immune globulin (anti-D prophylaxis) was introduced in 1968.